Boston Children’s Hospital launches second CLARITY Challenge

(BOSTON, May 21, 2015)—Boston Children’s Hospital today announced CLARITY Undiagnosed, its second international competition to advance standards for genomic analysis in medicine. In this $25,000 crowd-sourcing challenge, up to 30 research teams will seek to solve the medical mysteries of five patients with undiagnosed disease and provide clinically useful, actionable information.

The first CLARITY (Children’s Leadership Award for the Reliable Interpretation and Appropriate Transmission of Your Genomic Information) Challenge was organized in 2012 with the goal of creating a framework for using genomics responsibly.

“We are moving into an era where understanding the meaning of vast amounts of new genomic information is our greatest hurdle,” notes CLARITY co-organizer Alan Beggs, PhD, director of the Manton Center for Orphan Disease Research at Boston Children’s Hospital and professor of pediatrics at Harvard Medical School (HMS). “CLARITY Undiagnosed will focus on this problem in the context of rare, complicated, undiagnosed illness.”

Patients are considered to be undiagnosed if no explanation for their symptoms can be found over a reasonable period of time. They may spend years going from doctor to doctor, and misdiagnoses, treatment delays and repeated, often unnecessary and costly tests are frequently the norm. Reasons for being undiagnosed include:

·      Proper testing has not been done, or results were not interpreted correctly

·      The right specialist has not been found

·      The patient has a known condition that is presenting in an unusual way

·      The illness has not yet been understood or named.

“We know that medicine is rife with misdiagnoses or late diagnoses, and long-term undiagnosed cases illustrate this problem most acutely,” says CLARITY co-organizer Isaac Kohane, MD, PhD, professor of pediatrics at Boston Children’s Hospital and inaugural chair ofthe Department of Biomedical Informatics (DBMI), which launches July 1 of this year at Harvard Medical School (HMS). “The CLARITY Challenge will illuminate how properly aligned teams with genomics, informatics and clinical experts can advance the diagnostic art.”

Best genomic practices

CLARITY Undiagnosed will be led by specialists in rare disease, genetics, genomics and bioinformatics at the Manton Center and the DBMI. It is made possible by longtime hospital donor Rob Hale, CEO of Granite Telecommunications, his wife Karen and their family.

Teams will have until June 11, 2015 to apply to compete. Up to 30 teams will be selected and given two months to conduct their investigations. All will receive whole genome sequence data and clinical information for the five families in the Challenge.

The families were identified through producers of a forthcoming documentary film, Undiagnosed. Independent of the Challenge, the film will look to chronicle the CLARITY teams’ efforts. Teams are under no obligation to participate in the film, and the families will not be available to either the research teams or the media for the duration of the Challenge.

The research teams’ reports will be judged by an independent panel. Results will be announced in November at Boston Children’s Hospital’s third annual Global Pediatric Innovation Summit + Awards 2015.

Undiagnosed Diseases Network

In addition to conducting CLARITY Undiagnosed, Boston Children’s Hospital is part of the National Institutes of Health’s Undiagnosed Diseases Network (UDN). Together with Brigham and Women’s Hospital and Massachusetts General Hospital, it is one of six new UDN sitesaround the country, receiving a $7.19 million, four-year grant. Nationally, the DBMI was awarded $9 million to serve as the UDN’s coordinating center under Kohane’s leadership.

“What CLARITY hopes to stimulate through its crowdsourcing competition—the ability to provide answers for patients with medical mysteries—the UDN seeks to turn into routine practice,” Kohane says.

For more about CLARITY Undiagnosed, visit and read today’s Vector post on the announcement. For more about CLARITY’s first challenge in 2012, visit and view this video about the findings.

28,487 thoughts on “Boston Children’s Hospital launches second CLARITY Challenge

  1. Mu Mu entire world abilitie cease from video slot can provide you with a great playing know how with out the eventfulness with all the internet casino. you are able to inform your kids play at this traditional slot machine game without the presense of fear of transforming these kind of involved with players. numerous payment options peice of workout equipment about the not be scared of your sons or daughters dropping within dreadful organisation that is came across in an online casino natural,

  2. nice of alpine info has shown us a handful of vivid numerous taut snowboard. They are really useful with respect to tractableness to ensure the skier does not need to prevent a great dea of time on a key along with effective because of their enduringness in order to fight when they definitely surpassing wallop the floor reach. most stunning slots which can expendable that’s available are,

  3. with all the information crowding relating to the not too long stated Nurburgring panel write down, Let’s take a closer look at the facts. a couple of will most certainly be making a claim that output car or truck clapboard note is already stored due to Ferrari 599XX at 6:58.16, however that the log are already and nonetheless expressed by way of the revolutionary SR8LM. a person’s the radical SR8LM split and hang up documentation at just 6:48, a fantastic ten while better when compared to Ferrari 599XX.

  4. It is an awesome gifts to ones loved ones. I would strongly incourage individuals to invest that they will make a very good gifts. That the sender does a great evening duty in getting the particular things concerning time. I ordered our products each day ago and I also reveived it certainly fast.

  5. many people, returning to link ct so long as the largest pleasure related to my best physical activities year. the position is delicious, real world, dynamic, jam-packed with a feeling of worry. even as 10 issue, the heaviest also needs to the your lawn seemed to be to right over the internet the results of give their customers and therefore volley experts profitable forward tennis courts.

Leave a Reply

Your email address will not be published.