Boston Children’s Hospital launches second CLARITY Challenge

(BOSTON, May 21, 2015)—Boston Children’s Hospital today announced CLARITY Undiagnosed, its second international competition to advance standards for genomic analysis in medicine. In this $25,000 crowd-sourcing challenge, up to 30 research teams will seek to solve the medical mysteries of five patients with undiagnosed disease and provide clinically useful, actionable information.

The first CLARITY (Children’s Leadership Award for the Reliable Interpretation and Appropriate Transmission of Your Genomic Information) Challenge was organized in 2012 with the goal of creating a framework for using genomics responsibly.

“We are moving into an era where understanding the meaning of vast amounts of new genomic information is our greatest hurdle,” notes CLARITY co-organizer Alan Beggs, PhD, director of the Manton Center for Orphan Disease Research at Boston Children’s Hospital and professor of pediatrics at Harvard Medical School (HMS). “CLARITY Undiagnosed will focus on this problem in the context of rare, complicated, undiagnosed illness.”

Patients are considered to be undiagnosed if no explanation for their symptoms can be found over a reasonable period of time. They may spend years going from doctor to doctor, and misdiagnoses, treatment delays and repeated, often unnecessary and costly tests are frequently the norm. Reasons for being undiagnosed include:

·      Proper testing has not been done, or results were not interpreted correctly

·      The right specialist has not been found

·      The patient has a known condition that is presenting in an unusual way

·      The illness has not yet been understood or named.

“We know that medicine is rife with misdiagnoses or late diagnoses, and long-term undiagnosed cases illustrate this problem most acutely,” says CLARITY co-organizer Isaac Kohane, MD, PhD, professor of pediatrics at Boston Children’s Hospital and inaugural chair ofthe Department of Biomedical Informatics (DBMI), which launches July 1 of this year at Harvard Medical School (HMS). “The CLARITY Challenge will illuminate how properly aligned teams with genomics, informatics and clinical experts can advance the diagnostic art.”

Best genomic practices

CLARITY Undiagnosed will be led by specialists in rare disease, genetics, genomics and bioinformatics at the Manton Center and the DBMI. It is made possible by longtime hospital donor Rob Hale, CEO of Granite Telecommunications, his wife Karen and their family.

Teams will have until June 11, 2015 to apply to compete. Up to 30 teams will be selected and given two months to conduct their investigations. All will receive whole genome sequence data and clinical information for the five families in the Challenge.

The families were identified through producers of a forthcoming documentary film, Undiagnosed. Independent of the Challenge, the film will look to chronicle the CLARITY teams’ efforts. Teams are under no obligation to participate in the film, and the families will not be available to either the research teams or the media for the duration of the Challenge.

The research teams’ reports will be judged by an independent panel. Results will be announced in November at Boston Children’s Hospital’s third annual Global Pediatric Innovation Summit + Awards 2015.

Undiagnosed Diseases Network

In addition to conducting CLARITY Undiagnosed, Boston Children’s Hospital is part of the National Institutes of Health’s Undiagnosed Diseases Network (UDN). Together with Brigham and Women’s Hospital and Massachusetts General Hospital, it is one of six new UDN sitesaround the country, receiving a $7.19 million, four-year grant. Nationally, the DBMI was awarded $9 million to serve as the UDN’s coordinating center under Kohane’s leadership.

“What CLARITY hopes to stimulate through its crowdsourcing competition—the ability to provide answers for patients with medical mysteries—the UDN seeks to turn into routine practice,” Kohane says.

For more about CLARITY Undiagnosed, visit and read today’s Vector post on the announcement. For more about CLARITY’s first challenge in 2012, visit and view this video about the findings.

30,792 thoughts on “Boston Children’s Hospital launches second CLARITY Challenge

  1. This one headset had been since breathtaking because in visualize. That it came quickly. I would recommend getting a towel over each and every level as you press this away w / any steam iron. It doesn’t vapor over using merely a steamer. The iron had been essential. It is very fragile, so if you do not trust your self aided by the towel and/or steam iron, after that consume it to a expert. Striking appear.

  2. The headset was as breathtaking like within the image. That arrived promptly. I’d encourage choosing a towel more than each coating while you press information technology off w / one steam iron. It doesn’t vapor outside alongside only a steamer. On iron is needed. It is very fine, when you cannot trust your self with all the towel additionally vapor iron, next choose things to a expert. Pretty sound.

  3. Our headset was while breathtaking because into the picture. That appeared quickly. I’d suggest using a towel over each and every layer as you push things off w / your steam iron. It doesn’t vapor off alongside merely a steamer. Some sort of iron had been necessary. It can be sensitive, when you never trust yourself using the towel and also steam iron, after that consume that it up to a professional. Stunning noise.

  4. Needed to put you one little bit of observation to help thank you so much once again about the nice basics you’ve shown on this page. This is so seriously generous with you to deliver freely just what numerous people could have marketed as an ebook to end up making some profit for their own end, mostly since you could possibly have done it in case you wanted. Those concepts in addition worked as a great way to comprehend someone else have a similar dream much like my very own to understand more in regard to this condition. I know there are several more pleasant moments up front for many who look over your website.

  5. Our headset is because spectacular like inside image. They came immediately. I’d advise choosing a towel through every single coating while you press that out w / letter steam iron. It does not vapor away among only a steamer. Some sort of iron was appropriate. It is very delicate, when you you should not trust your self with the towel then vapor iron, subsequently bring this to a pro. Stunning noise.

  6. アディダスの通販専門店。アディダス スニーカー、アディダス リュック、アディダス Tシャツ、アディダス 時計、アディダス キャップ、アディダス iphone ケース、アディダス オリジナルスの総合通販。どこよりも品揃えも豊富です! カテゴリー:アディダス 時計

  7. Your headset was like stunning as in photo. This came immediately. I’d recommend utilizing a towel during every one coating as you push this outside w / letter steam iron. It does not steam away through merely a steamer. On iron had been appropriate. It can be fragile, so if you don’t trust your self using the towel then steam iron, then choose they to a expert. Striking seem.

  8. Our headset had been as breathtaking because within the photo. That it came immediately. I would recommend utilizing a towel during each layer while you click it out w / your vapor iron. It doesn’t vapor out and only a steamer. That the iron ended up being essential. It is very fragile, so if you don’t trust your self with all the towel furthermore vapor iron, therefore consume things to a professional. Striking audio.

  9. Unquestionably believe that which you said. Your favorite reason appeared to be on the web the simplest thing to be aware of. I say to you, I definitely get irked while people consider worries that they just don’t know about. You managed to hit the nail upon the top and also defined out the whole thing without having side effect , people can take a signal. Will likely be back to get more. Thanks

  10. I believe that is one of the such a lot important
    info for me. And i am happy reading your article.
    However should statement on some common things, The site style is ideal,
    the articles is really nice : D. Excellent activity, cheers

  11. YSL イブサンローラン 財布|イヴサンローランのショッピング通販のオンラインショップでは、イヴサンローラン Tシャツ、ベルト、パーカーセット、パーカーなど豊富な商品をラインナップ。【期間限 定】ネット注文なら10,000円( 税別)以上購入で全国どこでも ◇送料無料! カテゴリー:YSL イブサンローラン 財布

  12. Recieved it item prior to the day offered in a really wonderful present box . The actual picture that’s presented for bracelet is actually exactly what you will definitely recieve. This is certainly quite delicate yet any gorgeous section concerning jewelry which will continue due iof all toggle clasp and that is very robust so that the bracelet eill maybe not be removed.

  13. Pretty element of content. I simply stumbled upon your site and in accession capital to say that I get actually loved account your blog posts. Anyway I’ll be subscribing on your augment and even I achievement you get admission to constantly rapidly.

  14. I have it gifts to my personal mom of Christmas considering she was the best jewelry freak. All one thing she cannot wear far regarding is actually, bracelets. I bought this girl your appeal bracelet to after she opened up it yesterday she absolutley adored information technology! Nowadays the problem is, her getting they upon as well as off with herself. Haha… overall very good product or service, that transported as well as arrived massively early to my mother is actually enjoying they. Thank one.

Leave a Reply

Your email address will not be published.